Chronic Traumatic Encephalopathy (CTE)

As of now, there is no specific treatment for Chronic Traumatic Encephalopathy (CTE), and the condition can only be definitively diagnosed post-mortem. However, researchers are exploring various approaches to manage symptoms and slow disease progression. One promising area of research involves the use of nanoparticles (NPs), including Au (gold) nanoparticles, which could potentially offer new therapeutic strategies.

• • Gold Nanoparticles (Au NPs): Research is ongoing to explore the use of Au NPs as a therapeutic agent for neurodegenerative diseases, including CTE. These particles can cross the blood-brain barrier and deliver drugs or act as therapeutic agents themselves. They have shown potential in reducing inflammation and oxidative stress, which are key factors in CTE progression.

  • Research and Clinical Trials: Emerging therapies are being developed and tested in clinical trials. These include new drugs and therapies that could potentially revolutionize the treatment of CTE. Collaboration among neurologists, geneticists, bioengineers, and other experts is driving progress in understanding and treating CTE.

  While Au NPs show promise, more research is needed to fully understand their efficacy and safety in treating CTE.

• References

  Chronic traumatic encephalopathy (wikipedia)

  1. McKee, A. C., et al. (2013). The spectrum of disease in chronic traumatic encephalopathy. Brain, 136(1), 43-64.

  2. Stern, R. A., et al. (2019). Clinical presentation of chronic traumatic encephalopathy. Neurology, 92(8), e1006-e1015.

  3. Asken, B. M., et al. (2017). Research gaps and controversies in chronic traumatic encephalopathy: a review. JAMA Neurology, 74(10), 1255-1262.

  4. Mez, J., et al. (2017). Clinicopathological evaluation of chronic traumatic encephalopathy in players of American football. JAMA, 318(4), 360-370.

  5. Baugh, C. M., et al. (2012). Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma. Brain Imaging and Behavior, 6(2), 244-254.

  6. Omalu, B. I., et al. (2005). Chronic traumatic encephalopathy in a National Football League player. Neurosurgery, 57(1), 128-134.

  7. Stein, T. D., et al. (2014). Chronic traumatic encephalopathy: a spectrum of neuropathological changes following repetitive brain trauma in athletes and military personnel. Alzheimer’s Research & Therapy, 6(1), 4.

  8. Alosco, M. L., et al. (2018). Conceptualizing chronic traumatic encephalopathy as a continuum of disease. Alzheimer’s Research & Therapy, 10(1), 20.

  9. Gavett, B. E., et al. (2011). Chronic traumatic encephalopathy: a potential late effect of sport-related concussive and subconcussive head trauma. Clinics in Sports Medicine, 30(1), 179-188.

  10. Montenigro, P. H., et al. (2017). Clinical subtypes of chronic traumatic encephalopathy: literature review and proposed research diagnostic criteria for traumatic encephalopathy syndrome. Alzheimer’s Research & Therapy, 9(1), 25.